Head to Head Contrast: Vaxart (VXRT) vs. Seattle Genetics (SGEN)

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Vaxart (NASDAQ:VXRT) and Seattle Genetics (NASDAQ:SGEN) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their valuation, institutional ownership, earnings, risk, profitability, analyst recommendations and dividends.

Volatility and Risk

Vaxart has a beta of 0.57, indicating that its share price is 43% less volatile than the S&P 500. Comparatively, Seattle Genetics has a beta of 2.04, indicating that its share price is 104% more volatile than the S&P 500.


This table compares Vaxart and Seattle Genetics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Vaxart -330.79% -198.56% -40.81%
Seattle Genetics -26.58% -19.13% -16.36%

Analyst Recommendations

This is a summary of recent ratings and price targets for Vaxart and Seattle Genetics, as provided by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vaxart 0 0 0 0 N/A
Seattle Genetics 1 3 9 0 2.62

Seattle Genetics has a consensus price target of $79.73, indicating a potential upside of 11.65%. Given Seattle Genetics’ higher possible upside, analysts plainly believe Seattle Genetics is more favorable than Vaxart.

Institutional and Insider Ownership

9.2% of Vaxart shares are held by institutional investors. 44.8% of Vaxart shares are held by insiders. Comparatively, 33.8% of Seattle Genetics shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Earnings and Valuation

This table compares Vaxart and Seattle Genetics’ gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Vaxart $8.90 million 1.72 -$3.40 million N/A N/A
Seattle Genetics $482.25 million 23.71 -$125.53 million ($0.88) -81.15

Vaxart has higher earnings, but lower revenue than Seattle Genetics.


Seattle Genetics beats Vaxart on 8 of the 11 factors compared between the two stocks.

About Vaxart

Vaxart, Inc., a clinical-stage company, focuses on developing oral recombinant vaccines based on its proprietary oral vaccine delivery platform. The company's platform delivers various recombinant protein antigens, such as those used in influenza, hepatitis B, and human papilloma virus (HPV) vaccines, as well as other recombinant vaccines. Its development programs include oral tablet vaccines that are designed to protect against norovirus, seasonal influenza, and respiratory syncytial virus, as well as a therapeutic vaccine for HPV. The company is headquartered in South San Francisco, California.

About Seattle Genetics

Seattle Genetics, Inc., a biotechnology company, focuses on the development and commercialization of targeted therapies for the treatment of cancer worldwide. It markets ADCETRIS, an antibody-drug conjugate for the treatment of relapsed Hodgkin lymphoma and relapsed systemic anaplastic large cell lymphoma. The company also develops enfortumab vedotin, which is in Phase 1 clinical trial for Nectin-4-positive solid tumors, including bladder cancer; and tisotumab vedotin that is in Phase II clinical trial for patients with cervical cancer and solid tumors. In addition, it conducts phase 3 clinical trials of ADCETRIS which includes ECHELON-1 for patients with newly diagnosed advanced stage classical Hodgkin lymphoma; ECHELON-2 for patients with newly diagnosed CD30-expressing MTCL; and the CHECKMATE 812 for patients with relapsed or refractory or transplant-ineligible, and advanced classical Hodgkin lymphoma. Further, the company's earlier stage clinical pipeline includes six other ADC programs consisting of ladiratuzumab vedotin, denintuzumab mafodotin, SGN-CD19B, SGN-CD123A, SGN-CD33A, and SGN-CD352A, as well as two immuno-oncology agents, including SEA-CD40 and SGN-2FF. It has collaborations for its ADC technology with various biotechnology and pharmaceutical companies, including AbbVie Biotechnology Ltd.; Bayer Pharma AG; Celldex Therapeutics, Inc.; Genentech, Inc.; GlaxoSmithKline LLC; Pfizer, Inc., PSMA Development Company LLC; Takeda Pharmaceutical Company Limited, Unum Therapeutics, Inc., and Genmab A/S, as well as has co-development agreement with Agensys, Inc. Seattle Genetics, Inc. was founded in 1998 and is headquartered in Bothell, Washington.

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